:root {
    --ink: #0D1E35;
    --ink-mid: #2A3A47;
    --ink-soft: #6B7785;
    --ink-mute: #C0C7CE;
    --white: #FFFFFF;
    --bg: #F4F2EC;
    --bg-warm: #EDEAE2;
    --bg-soft: #F0F4F2;
    --bg-card: #FFFFFF;
    --rule: #DCD8CE;
    --rule-soft: #E7E4DA;
    --teal: #006B6B;
    --teal-bright: #5BBAB5;
    --teal-lt: #E8F4F2;
    --teal-pale: #F0F8F7;
    --amber: #C8923A;
    --amber-lt: #F7E6B8;
    --amber-soft: #FBF1D2;
    --rose: #B8455C;
    --rose-lt: #FAE6EA;
    --sun: #F5C75A;
    --sage: #4B8B6A;
    --sage-lt: #E6F0EA;
    --ease-out: cubic-bezier(.2,.8,.2,1);
    --ease-spring: cubic-bezier(.32,.72,0,1);
    --shadow-card: 0 1px 2px rgba(13,30,53,.04),0 8px 24px -8px rgba(13,30,53,.08);
    --shadow-soft: 0 2px 4px rgba(13,30,53,.04),0 20px 48px -16px rgba(13,30,53,.12);
    --shadow-warm: 0 2px 6px rgba(200,146,58,.06),0 30px 80px -20px rgba(13,30,53,.14);
}

*, *::before, *::after {
    box-sizing: border-box;
    margin: 0;
    padding: 0
}

html {
    scroll-behavior: smooth;
    -webkit-text-size-adjust: 100%
}

body {
    font-family: 'Plus Jakarta Sans',-apple-system,BlinkMacSystemFont,system-ui,sans-serif;
    background: var(--bg);
    color: var(--ink);
    font-weight: 300;
    line-height: 1.5;
    -webkit-font-smoothing: antialiased;
    -moz-osx-font-smoothing: grayscale;
    overflow-x: hidden
}

a {
    color: inherit;
    text-decoration: none
}

img, svg {
    max-width: 100%;
    display: block
}

button {
    font: inherit;
    color: inherit;
    background: none;
    border: none;
    cursor: pointer
}

ul, ol {
    list-style: none
}

body::before {
    content: '';
    position: fixed;
    inset: 0;
    z-index: 2000;
    pointer-events: none;
    opacity: .016;
    background-image: url("data:image/svg+xml;utf8,<svg xmlns='http://www.w3.org/2000/svg' width='200' height='200'><filter id='n'><feTurbulence type='fractalNoise' baseFrequency='0.9' numOctaves='2' stitchTiles='stitch'/></filter><rect width='100%25' height='100%25' filter='url(%23n)'/></svg>");
    mix-blend-mode: multiply
}

.container {
    max-width: 1280px;
    margin: 0 auto;
    padding: 0 40px
}

@media (max-width:899px) {
    .container {
        padding: 0 24px
    }
}

@media (max-width:480px) {
    .container {
        padding: 0 20px
    }
}

.eyebrow {
    display: inline-flex;
    align-items: center;
    gap: 12px;
    font-size: 11px;
    font-weight: 600;
    letter-spacing: .22em;
    text-transform: uppercase;
    color: var(--amber)
}

    .eyebrow::before {
        content: '';
        width: 32px;
        height: 1px;
        background: var(--amber);
        opacity: .5
    }
     
/* HERO */
.tx-hero {
    padding: 80px 0 60px;
    border-bottom: 1px solid var(--rule);
    position: relative;
    overflow: hidden;
    background: var(--bg)
}

    .tx-hero::before {
        content: '';
        position: absolute;
        right: -180px;
        top: 60px;
        width: 520px;
        height: 520px;
        border-radius: 50%;
        border: 1px solid var(--rule);
        pointer-events: none;
        opacity: .6
    }

    .tx-hero::after {
        content: '';
        position: absolute;
        right: -60px;
        top: 180px;
        width: 300px;
        height: 300px;
        border-radius: 50%;
        border: 1px solid var(--rule);
        pointer-events: none;
        opacity: .6
    }

.breadcrumb {
    display: flex;
    gap: 8px;
    align-items: center;
    font-size: 11px;
    letter-spacing: .12em;
    text-transform: uppercase;
    color: var(--ink-soft);
    margin-bottom: 32px;
    position: relative;
    z-index: 1;
    flex-wrap: wrap
}

    .breadcrumb a {
        color: var(--ink-soft);
        transition: color .25s
    }

        .breadcrumb a:hover {
            color: var(--teal)
        }

    .breadcrumb .sep {
        opacity: .5
    }

    .breadcrumb .current {
        color: var(--ink);
        font-weight: 500
    }

.tx-hero-grid {
    display: grid;
    grid-template-columns: 1.3fr 1fr;
    gap: 72px;
    align-items: start;
    position: relative;
    z-index: 1
}

@media (max-width:960px) {
    .tx-hero-grid {
        grid-template-columns: 1fr;
        gap: 48px
    }
}

.tx-isotope-row {
    display: flex;
    flex-wrap: wrap;
    gap: 8px;
    margin-bottom: 20px
}

.tx-isotope {
    display: inline-flex;
    align-items: center;
    gap: 8px;
    padding: 6px 14px;
    background: var(--white);
    border: 1px solid var(--rule);
    border-radius: 999px;
    box-shadow: var(--shadow-card)
}

.tx-isotope-num {
    font-family: 'Cormorant Garamond',serif;
    font-size: 14px;
    color: var(--amber);
    font-weight: 500
}

    .tx-isotope-num sup {
        font-size: 9px;
        vertical-align: super
    }

.tx-isotope-name {
    font-size: 10.5px;
    font-weight: 600;
    color: var(--ink);
    letter-spacing: .08em;
    text-transform: uppercase
}

.tx-title {
    font-family: 'Cormorant Garamond',serif;
    font-size: clamp(42px,5.8vw,76px);
    font-weight: 300;
    line-height: 1.02;
    letter-spacing: -.018em;
    color: var(--ink);
    margin-bottom: 24px
}

    .tx-title em {
        font-style: italic;
        color: var(--teal)
    }

.tx-summary {
    font-family: 'Cormorant Garamond',serif;
    font-style: italic;
    font-size: 20px;
    font-weight: 300;
    color: var(--ink-mid);
    line-height: 1.55;
    margin-bottom: 32px;
    max-width: 640px
}

.tx-byline {
    display: flex;
    align-items: center;
    gap: 18px;
    padding: 18px 0;
    border-top: 1px solid var(--rule);
    border-bottom: 1px solid var(--rule);
    margin-bottom: 32px;
    flex-wrap: wrap
}

.tx-byline-author {
    display: flex;
    align-items: center;
    gap: 14px
}

.tx-byline-avatar {
    width: 48px;
    height: 48px;
    border-radius: 50%;
    background: linear-gradient(135deg,var(--teal-pale) 0%,var(--bg-warm) 100%);
    border: 1px solid var(--rule);
    flex-shrink: 0;
    display: flex;
    align-items: center;
    justify-content: center;
    font-family: 'Cormorant Garamond',serif;
    font-style: italic;
    font-size: 18px;
    color: var(--teal);
    font-weight: 400
}

.tx-byline-meta {
    font-size: 13px;
    color: var(--ink-soft);
    line-height: 1.5
}

    .tx-byline-meta strong {
        color: var(--ink);
        font-weight: 600;
        font-size: 13.5px
    }

    .tx-byline-meta a {
        color: var(--teal);
        transition: color .25s
    }

        .tx-byline-meta a:hover {
            color: var(--ink)
        }

.tx-byline-badge {
    display: inline-flex;
    align-items: center;
    gap: 6px;
    padding: 6px 14px;
    background: var(--sage-lt);
    color: var(--sage);
    border-radius: 999px;
    font-size: 10px;
    font-weight: 600;
    letter-spacing: .14em;
    text-transform: uppercase
}

    .tx-byline-badge::before {
        content: '';
        width: 6px;
        height: 6px;
        border-radius: 50%;
        background: var(--sage)
    }

.tx-hero-ctas {
    display: flex;
    gap: 12px;
    flex-wrap: wrap
}

.btn {
    display: inline-flex;
    align-items: center;
    gap: 10px;
    padding: 14px 8px 14px 24px;
    border-radius: 999px;
    font-size: 13px;
    font-weight: 600;
    letter-spacing: .04em;
    transition: all .4s var(--ease-spring)
}

.btn-primary {
    background: var(--ink);
    color: var(--white)
}

    .btn-primary:hover {
        background: var(--teal);
        transform: translateY(-1px)
    }

.btn-secondary {
    background: var(--white);
    color: var(--ink);
    border: 1px solid var(--rule)
}

    .btn-secondary:hover {
        border-color: var(--teal);
        color: var(--teal);
        transform: translateY(-1px)
    }

.btn-arrow {
    display: inline-flex;
    align-items: center;
    justify-content: center;
    width: 30px;
    height: 30px;
    border-radius: 50%;
    transition: transform .4s var(--ease-spring)
}

.btn-primary .btn-arrow {
    background: rgba(255,255,255,.14)
}

.btn-secondary .btn-arrow {
    background: var(--bg-warm)
}

.btn:hover .btn-arrow {
    transform: translateX(3px) rotate(-45deg)
}

.btn svg {
    width: 14px;
    height: 14px
}

/* QUICK FACTS */
.tx-facts {
    background: rgba(13,30,53,.04);
    border: 1px solid var(--rule);
    border-radius: 20px;
    padding: 10px;
    position: relative;
    z-index: 1
}

.tx-facts-inner {
    background: var(--white);
    border-radius: 14px;
    padding: 30px 28px;
    box-shadow: inset 0 1px 1px rgba(255,255,255,.6)
}

.tx-facts-head {
    display: flex;
    justify-content: space-between;
    align-items: center;
    padding-bottom: 16px;
    border-bottom: 1px solid var(--rule);
    margin-bottom: 12px
}

.tx-facts-label {
    font-size: 10px;
    font-weight: 600;
    letter-spacing: .22em;
    text-transform: uppercase;
    color: var(--amber)
}

.tx-facts-code {
    font-family: 'Cormorant Garamond',serif;
    font-style: italic;
    font-size: 13px;
    color: var(--ink-soft)
}

.tx-fact {
    display: grid;
    grid-template-columns: 100px 1fr;
    gap: 16px;
    padding: 12px 0;
    border-bottom: 1px solid var(--rule-soft)
}

    .tx-fact:last-child {
        border-bottom: none
    }

.tx-fact-label {
    font-size: 10.5px;
    letter-spacing: .1em;
    text-transform: uppercase;
    color: var(--ink-soft);
    font-weight: 600;
    padding-top: 3px
}

.tx-fact-value {
    font-size: 13.5px;
    color: var(--ink);
    font-weight: 400;
    line-height: 1.5
}

    .tx-fact-value em {
        font-family: 'Cormorant Garamond',serif;
        font-style: italic;
        color: var(--teal)
    }

    .tx-fact-value strong {
        font-weight: 600
    }

/* BODY 3-COL */
.tx-body {
    padding: 80px 0 100px;
    background: var(--bg)
}

.tx-body-grid {
    display: grid;
    grid-template-columns: 220px 1fr 280px;
    gap: 56px;
    align-items: start
}

@media (max-width:1100px) {
    .tx-body-grid {
        grid-template-columns: 1fr;
        gap: 48px
    }
}

.tx-toc {
    position: sticky;
    top: 108px
}

@media (max-width:1100px) {
    .tx-toc {
        position: static
    }
}

.tx-toc-label {
    font-size: 10px;
    font-weight: 600;
    letter-spacing: .22em;
    text-transform: uppercase;
    color: var(--ink-soft);
    margin-bottom: 18px
}

.tx-toc-list {
    list-style: none;
    padding: 0;
    margin: 0;
    display: flex;
    flex-direction: column;
    gap: 2px
}

    .tx-toc-list a {
        display: block;
        padding: 10px 14px;
        font-size: 12.5px;
        color: var(--ink-soft);
        border-left: 2px solid transparent;
        border-radius: 0 8px 8px 0;
        transition: all .2s;
        line-height: 1.45
    }

        .tx-toc-list a:hover {
            color: var(--ink);
            background: var(--white)
        }

        .tx-toc-list a.active {
            color: var(--ink);
            background: var(--white);
            border-left-color: var(--amber);
            font-weight: 500
        }

.tx-rail {
    position: sticky;
    top: 108px;
    display: flex;
    flex-direction: column;
    gap: 14px
}

@media (max-width:1100px) {
    .tx-rail {
        position: static
    }
}

.tx-rail-shell {
    background: rgba(13,30,53,.04);
    border: 1px solid var(--rule);
    border-radius: 18px;
    padding: 8px
}

.tx-rail-card {
    background: var(--white);
    border-radius: 12px;
    padding: 22px;
    box-shadow: inset 0 1px 1px rgba(255,255,255,.6)
}

    .tx-rail-card.dark {
        background: var(--ink);
        color: var(--white);
        box-shadow: none
    }

        .tx-rail-card.dark .tx-rail-title {
            color: var(--white)
        }

        .tx-rail-card.dark .tx-rail-desc {
            color: rgba(255,255,255,.65)
        }

.tx-rail-label {
    font-size: 10px;
    font-weight: 600;
    letter-spacing: .2em;
    text-transform: uppercase;
    color: var(--amber);
    margin-bottom: 10px
}

.tx-rail-card.dark .tx-rail-label {
    color: var(--sun)
}

.tx-rail-title {
    font-family: 'Cormorant Garamond',serif;
    font-size: 21px;
    font-weight: 400;
    color: var(--ink);
    line-height: 1.25;
    margin-bottom: 8px
}

    .tx-rail-title em {
        font-style: italic;
        color: var(--teal)
    }

.tx-rail-card.dark .tx-rail-title em {
    color: var(--teal-bright)
}

.tx-rail-desc {
    font-size: 13px;
    font-weight: 300;
    color: var(--ink-soft);
    line-height: 1.6;
    margin-bottom: 16px
}

.tx-rail-btn {
    display: inline-flex;
    align-items: center;
    justify-content: center;
    gap: 8px;
    padding: 12px 18px;
    width: 100%;
    background: var(--ink);
    color: var(--white);
    border-radius: 999px;
    font-size: 11px;
    font-weight: 600;
    letter-spacing: .1em;
    text-transform: uppercase;
    transition: all .25s var(--ease-spring);
    font-family: inherit
}

    .tx-rail-btn:hover {
        background: var(--teal);
        transform: translateY(-1px)
    }

    .tx-rail-btn.alt {
        background: transparent;
        color: var(--ink);
        border: 1px solid var(--rule)
    }

        .tx-rail-btn.alt:hover {
            background: var(--ink);
            color: var(--white);
            border-color: var(--ink)
        }

.tx-rail-card.dark .tx-rail-btn {
    background: var(--white);
    color: var(--ink)
}

    .tx-rail-card.dark .tx-rail-btn:hover {
        background: var(--teal-bright)
    }

/* CONTENT */
.tx-content {
    max-width: 740px
}

.tx-section {
    margin-bottom: 64px;
    scroll-margin-top: 108px
}

.tx-section-num {
    font-family: 'Cormorant Garamond',serif;
    font-style: italic;
    font-size: 14px;
    color: var(--amber);
    margin-bottom: 10px;
    display: block;
    letter-spacing: .02em
}

.tx-section h2 {
    font-family: 'Cormorant Garamond',serif;
    font-size: clamp(30px,3.8vw,44px);
    font-weight: 300;
    line-height: 1.08;
    color: var(--ink);
    margin-bottom: 22px;
    letter-spacing: -.01em
}

    .tx-section h2 em {
        font-style: italic;
        color: var(--teal)
    }

.tx-section h3 {
    font-family: 'Cormorant Garamond',serif;
    font-size: 23px;
    font-weight: 500;
    color: var(--ink);
    margin: 32px 0 12px;
    line-height: 1.25
}

    .tx-section h3 em {
        font-style: italic;
        color: var(--teal);
        font-weight: 400
    }

.tx-section p {
    font-size: 16px;
    font-weight: 300;
    line-height: 1.85;
    color: var(--ink-mid);
    margin-bottom: 18px
}

    .tx-section p strong {
        font-weight: 500;
        color: var(--ink)
    }

    .tx-section p em {
        font-style: italic
    }

.tx-section a {
    color: var(--teal);
    border-bottom: 1px solid var(--rule);
    transition: border-color .25s
}

    .tx-section a:hover {
        border-bottom-color: var(--teal)
    }

.tx-section ul {
    margin: 18px 0 22px;
    display: flex;
    flex-direction: column;
    gap: 10px
}

    .tx-section ul li {
        font-size: 15.5px;
        font-weight: 300;
        line-height: 1.75;
        color: var(--ink-mid);
        padding-left: 24px;
        position: relative
    }

        .tx-section ul li::before {
            content: '';
            width: 6px;
            height: 6px;
            border-radius: 50%;
            background: var(--amber);
            position: absolute;
            left: 6px;
            top: 10px
        }

        .tx-section ul li strong {
            font-weight: 500;
            color: var(--ink)
        }

.tx-aag {
    background: var(--amber-soft);
    border-left: 3px solid var(--amber);
    border-radius: 0 10px 10px 0;
    padding: 24px 28px;
    margin: 0 0 32px
}

.tx-aag-label {
    font-size: 10px;
    font-weight: 600;
    letter-spacing: .22em;
    text-transform: uppercase;
    color: var(--amber);
    margin-bottom: 10px
}

.tx-aag-text {
    font-family: 'Cormorant Garamond',serif;
    font-size: 21px;
    font-weight: 400;
    line-height: 1.55;
    color: var(--ink);
    font-style: italic;
    letter-spacing: -.005em
}

    .tx-aag-text em {
        font-style: normal;
        font-weight: 500;
        color: var(--amber)
    }

.tx-img {
    margin: 32px 0;
    background: linear-gradient(135deg,var(--amber-soft) 0%,var(--bg-warm) 100%);
    border: 1px solid var(--rule);
    border-radius: 14px;
    aspect-ratio: 16/9;
    display: flex;
    flex-direction: column;
    align-items: center;
    justify-content: center;
    text-align: center;
    padding: 40px;
    position: relative
}

    .tx-img::before {
        content: '';
        position: absolute;
        top: 20%;
        right: 15%;
        width: 50%;
        height: 50%;
        border-radius: 50%;
        border: 1px solid var(--amber);
        opacity: .2
    }

.tx-img-icon {
    font-family: 'Cormorant Garamond',serif;
    font-size: 54px;
    font-weight: 300;
    color: var(--amber);
    margin-bottom: 8px;
    letter-spacing: -.02em;
    line-height: 1
}

    .tx-img-icon sup {
        font-size: 26px;
        color: var(--ink);
        vertical-align: top;
        font-weight: 400
    }

.tx-img-caption {
    font-size: 11px;
    font-weight: 600;
    letter-spacing: .16em;
    text-transform: uppercase;
    color: var(--ink);
    margin-bottom: 6px
}

.tx-img-note {
    font-size: 11px;
    color: var(--ink-soft);
    font-style: italic;
    font-family: 'Cormorant Garamond',serif;
    letter-spacing: .04em;
    max-width: 520px
}

/* CANCERS GRID */
.tx-cancers {
    display: grid;
    grid-template-columns: repeat(2,1fr);
    gap: 10px;
    margin: 24px 0 32px
}

@media (max-width:580px) {
    .tx-cancers {
        grid-template-columns: 1fr
    }
}

.tx-cancer-card {
    padding: 18px 20px;
    background: var(--white);
    border: 1px solid var(--rule);
    border-radius: 10px;
    display: flex;
    flex-direction: column;
    gap: 6px;
    transition: all .25s
}

    .tx-cancer-card:hover {
        border-color: var(--amber);
        transform: translateY(-2px);
        box-shadow: var(--shadow-card)
    }

.tx-cancer-name {
    font-family: 'Cormorant Garamond',serif;
    font-size: 18px;
    font-weight: 500;
    color: var(--ink);
    line-height: 1.3
}

    .tx-cancer-name em {
        font-style: italic;
        color: var(--amber);
        font-weight: 400
    }

.tx-cancer-meta {
    font-size: 11.5px;
    color: var(--ink-soft);
    line-height: 1.5
}

/* THERANOSTIC PAIR */
.tx-pair {
    margin: 32px 0;
    background: var(--white);
    border: 1px solid var(--rule);
    border-radius: 14px;
    overflow: hidden;
    box-shadow: var(--shadow-card)
}

.tx-pair-grid {
    display: grid;
    grid-template-columns: 1fr auto 1fr;
    align-items: stretch
}

@media (max-width:640px) {
    .tx-pair-grid {
        grid-template-columns: 1fr
    }
}

.tx-pair-col {
    padding: 30px 32px
}

.tx-pair-divider {
    display: flex;
    align-items: center;
    justify-content: center;
    padding: 30px 0;
    background: var(--bg-warm)
}

@media (max-width:640px) {
    .tx-pair-divider {
        padding: 14px 0;
        transform: rotate(90deg)
    }
}

.tx-pair-arrow {
    width: 32px;
    height: 32px;
    border-radius: 50%;
    background: var(--amber);
    color: var(--white);
    display: flex;
    align-items: center;
    justify-content: center
}

    .tx-pair-arrow svg {
        width: 14px;
        height: 14px
    }

.tx-pair-flag {
    display: inline-block;
    padding: 5px 12px;
    border-radius: 999px;
    font-size: 10px;
    font-weight: 600;
    letter-spacing: .14em;
    text-transform: uppercase;
    margin-bottom: 14px;
    background: var(--teal-pale);
    color: var(--teal)
}

    .tx-pair-flag.therapy {
        background: var(--amber-soft);
        color: var(--amber)
    }

.tx-pair-h {
    font-family: 'Cormorant Garamond',serif;
    font-size: 22px;
    font-weight: 500;
    color: var(--ink);
    line-height: 1.25;
    margin-bottom: 10px
}

    .tx-pair-h em {
        font-style: italic;
        color: var(--teal);
        font-weight: 400
    }

.tx-pair-text {
    font-size: 14px;
    color: var(--ink-mid);
    line-height: 1.7;
    font-weight: 300;
    margin-bottom: 14px
}

.tx-pair-list {
    display: flex;
    flex-direction: column;
    gap: 6px
}

.tx-pair-item {
    font-size: 12.5px;
    color: var(--ink-mid);
    line-height: 1.5;
    display: flex;
    gap: 8px
}

    .tx-pair-item strong {
        color: var(--ink);
        font-weight: 500;
        letter-spacing: .02em
    }

    .tx-pair-item::before {
        content: '·';
        color: var(--amber);
        font-weight: 700
    }

/* ISOTOPE COMPARE */
.tx-iso-compare {
    margin: 32px 0;
    background: var(--white);
    border: 1px solid var(--rule);
    border-radius: 14px;
    overflow: hidden;
    box-shadow: var(--shadow-card)
}

.tx-iso-grid {
    display: grid;
    grid-template-columns: repeat(3,1fr)
}

@media (max-width:760px) {
    .tx-iso-grid {
        grid-template-columns: 1fr
    }
}

.tx-iso-col {
    padding: 26px 28px;
    border-right: 1px solid var(--rule)
}

    .tx-iso-col:last-child {
        border-right: none
    }

@media (max-width:760px) {
    .tx-iso-col {
        border-right: none;
        border-bottom: 1px solid var(--rule)
    }

        .tx-iso-col:last-child {
            border-bottom: none
        }
}

.tx-iso-tag {
    display: inline-block;
    padding: 5px 12px;
    border-radius: 999px;
    font-size: 10px;
    font-weight: 600;
    letter-spacing: .14em;
    text-transform: uppercase;
    margin-bottom: 14px
}

    .tx-iso-tag.beta {
        background: var(--teal-pale);
        color: var(--teal)
    }

    .tx-iso-tag.beta-hi {
        background: #E6EFF6;
        color: #5C7E9B
    }

    .tx-iso-tag.alpha {
        background: var(--amber-soft);
        color: var(--amber)
    }

.tx-iso-h {
    font-family: 'Cormorant Garamond',serif;
    font-size: 22px;
    font-weight: 500;
    color: var(--ink);
    line-height: 1.2;
    margin-bottom: 10px
}

    .tx-iso-h em {
        font-style: italic;
        color: var(--teal);
        font-weight: 400
    }

.tx-iso-desc {
    font-size: 13.5px;
    color: var(--ink-mid);
    line-height: 1.65;
    font-weight: 300;
    margin-bottom: 14px
}

.tx-iso-list {
    display: flex;
    flex-direction: column;
    gap: 6px
}

.tx-iso-li {
    font-size: 12px;
    color: var(--ink-mid);
    line-height: 1.5;
    display: flex;
    flex-direction: column;
    gap: 1px;
    padding: 4px 0;
    border-top: 1px solid var(--rule-soft)
}

    .tx-iso-li:first-child {
        border-top: none
    }

    .tx-iso-li strong {
        color: var(--ink);
        font-weight: 500;
        font-size: 10.5px;
        letter-spacing: .1em;
        text-transform: uppercase
    }

/* PROTOCOL STEPS */
.tx-steps {
    display: grid;
    grid-template-columns: 1fr 1fr;
    gap: 12px;
    margin: 28px 0
}

@media (max-width:580px) {
    .tx-steps {
        grid-template-columns: 1fr
    }
}

.tx-step {
    padding: 24px;
    background: var(--white);
    border: 1px solid var(--rule);
    border-radius: 12px;
    transition: all .3s
}

    .tx-step:hover {
        border-color: var(--amber);
        transform: translateY(-2px);
        box-shadow: var(--shadow-card)
    }

.tx-step-num {
    font-family: 'Cormorant Garamond',serif;
    font-style: italic;
    font-size: 24px;
    color: var(--amber);
    line-height: 1;
    margin-bottom: 12px
}

.tx-step-title {
    font-family: 'Cormorant Garamond',serif;
    font-size: 18px;
    font-weight: 500;
    color: var(--ink);
    margin-bottom: 8px;
    line-height: 1.3
}

.tx-step-body {
    font-size: 13.5px;
    font-weight: 300;
    color: var(--ink-mid);
    line-height: 1.65
}

.tx-callout {
    margin: 32px 0;
    padding: 24px 28px;
    background: var(--amber-soft);
    border-left: 3px solid var(--amber);
    border-radius: 0 8px 8px 0
}

.tx-callout-label {
    font-size: 10px;
    font-weight: 600;
    letter-spacing: .2em;
    text-transform: uppercase;
    color: var(--amber);
    margin-bottom: 8px
}

.tx-callout p {
    font-size: 14.5px;
    color: var(--ink-mid);
    line-height: 1.75;
    font-weight: 300;
    margin-bottom: 8px
}

    .tx-callout p:last-child {
        margin-bottom: 0
    }

.tx-callout strong {
    color: var(--ink);
    font-weight: 500
}

/* COST */
.tx-cost-wrap {
    margin: 28px 0;
    background: var(--white);
    border: 1px solid var(--rule);
    border-radius: 14px;
    overflow: hidden;
    box-shadow: var(--shadow-card)
}

.tx-cost {
    width: 100%;
    border-collapse: collapse;
    font-size: 14px
}

    .tx-cost thead {
        background: var(--amber-soft)
    }

    .tx-cost th {
        padding: 18px 20px;
        text-align: left;
        font-size: 10.5px;
        font-weight: 600;
        letter-spacing: .14em;
        text-transform: uppercase;
        color: var(--amber)
    }

    .tx-cost td {
        padding: 18px 20px;
        border-top: 1px solid var(--rule-soft);
        font-weight: 300;
        color: var(--ink-mid);
        vertical-align: top
    }

    .tx-cost tbody tr:hover {
        background: var(--bg-soft)
    }

.tx-cost-label {
    font-family: 'Cormorant Garamond',serif;
    font-size: 17px;
    font-weight: 500;
    color: var(--ink);
    line-height: 1.3
}

    .tx-cost-label em {
        font-style: italic;
        color: var(--amber);
        font-weight: 400
    }

.tx-cost-amount {
    font-weight: 500;
    color: var(--ink)
}

    .tx-cost-amount em {
        font-family: 'Cormorant Garamond',serif;
        font-style: italic;
        font-weight: 300;
        color: var(--ink-soft);
        font-size: 13px
    }

/* CALENDAR */
.tx-cal {
    margin: 32px 0
}

.tx-cal-head {
    display: flex;
    justify-content: space-between;
    align-items: flex-end;
    gap: 18px;
    margin-bottom: 18px;
    flex-wrap: wrap
}

.tx-cal-title {
    font-family: 'Cormorant Garamond',serif;
    font-size: 24px;
    font-weight: 500;
    color: var(--ink);
    line-height: 1.2
}

    .tx-cal-title em {
        font-style: italic;
        color: var(--amber);
        font-weight: 400
    }

.tx-cal-foot {
    font-size: 12px;
    color: var(--ink-soft);
    font-family: 'Cormorant Garamond',serif;
    font-style: italic
}

.tx-cal-grid {
    display: grid;
    grid-template-columns: repeat(3,1fr);
    gap: 12px
}

@media (max-width:760px) {
    .tx-cal-grid {
        grid-template-columns: repeat(2,1fr)
    }
}

@media (max-width:480px) {
    .tx-cal-grid {
        grid-template-columns: 1fr
    }
}

.tx-cal-slot {
    background: var(--white);
    border: 1px solid var(--rule);
    border-radius: 10px;
    padding: 16px 18px;
    transition: all .3s
}

    .tx-cal-slot:hover {
        border-color: var(--amber);
        transform: translateY(-2px);
        box-shadow: var(--shadow-card)
    }

.tx-cal-week {
    font-size: 10.5px;
    font-weight: 600;
    letter-spacing: .16em;
    text-transform: uppercase;
    color: var(--ink-soft);
    margin-bottom: 4px
}

.tx-cal-date {
    font-family: 'Cormorant Garamond',serif;
    font-size: 20px;
    font-weight: 500;
    color: var(--ink);
    margin-bottom: 8px;
    line-height: 1.2
}

    .tx-cal-date em {
        font-style: italic;
        color: var(--amber);
        font-weight: 400
    }

.tx-cal-isotope {
    font-size: 11.5px;
    color: var(--ink-mid);
    font-weight: 500;
    display: flex;
    align-items: center;
    gap: 8px
}

    .tx-cal-isotope::before {
        content: '';
        width: 8px;
        height: 8px;
        border-radius: 50%;
        background: var(--amber)
    }

.tx-cal-cta {
    margin-top: 12px;
    display: inline-flex;
    align-items: center;
    gap: 6px;
    font-size: 11px;
    color: var(--amber);
    font-weight: 600;
    letter-spacing: .06em;
    text-transform: uppercase
}

/* Countdown override styles */
.cal-cta-urgent {
    color: #C8923A !important;
    font-weight: 700 !important
}

.cal-cta-closed {
    color: #6B7785 !important;
    font-style: italic
}

.cal-slot-closed {
    opacity: .55;
    pointer-events: none
}

/* FAQ */
.tx-faq {
    margin-top: 48px;
    scroll-margin-top: 108px
}

    .tx-faq h2 {
        font-family: 'Cormorant Garamond',serif;
        font-size: 36px;
        font-weight: 300;
        color: var(--ink);
        margin-bottom: 22px;
        letter-spacing: -.005em
    }

        .tx-faq h2 em {
            font-style: italic;
            color: var(--teal)
        }

.faq-row {
    border-bottom: 1px solid var(--rule)
}

    .faq-row:first-of-type {
        border-top: 1px solid var(--rule)
    }

.faq-q {
    width: 100%;
    background: transparent;
    border: none;
    padding: 22px 0;
    cursor: pointer;
    font-family: inherit;
    text-align: left;
    display: flex;
    justify-content: space-between;
    align-items: flex-start;
    gap: 24px;
    transition: color .2s
}

    .faq-q:hover .faq-q-text {
        color: var(--amber)
    }

.faq-q-text {
    font-family: 'Cormorant Garamond',serif;
    font-size: 21px;
    font-weight: 400;
    color: var(--ink);
    line-height: 1.4;
    flex: 1;
    transition: color .2s
}

    .faq-q-text em {
        font-style: italic;
        color: var(--amber)
    }

.faq-toggle {
    flex-shrink: 0;
    width: 30px;
    height: 30px;
    border-radius: 50%;
    border: 1px solid var(--rule);
    display: flex;
    align-items: center;
    justify-content: center;
    position: relative;
    transition: all .3s var(--ease-spring);
    background: var(--white)
}

    .faq-toggle::before, .faq-toggle::after {
        content: '';
        position: absolute;
        background: var(--ink);
        transition: all .3s
    }

    .faq-toggle::before {
        width: 11px;
        height: 1.5px
    }

    .faq-toggle::after {
        width: 1.5px;
        height: 11px
    }

.faq-row.open .faq-toggle {
    background: var(--amber);
    border-color: var(--amber);
    transform: rotate(45deg)
}

    .faq-row.open .faq-toggle::before, .faq-row.open .faq-toggle::after {
        background: var(--white)
    }

.faq-a {
    max-height: 0;
    overflow: hidden;
    transition: max-height .4s var(--ease-spring),padding .3s
}

.faq-row.open .faq-a {
    max-height: 800px;
    padding: 0 0 26px
}

.faq-a-inner {
    font-size: 15px;
    font-weight: 300;
    color: var(--ink-mid);
    line-height: 1.85;
    max-width: 680px
}

    .faq-a-inner p {
        margin-bottom: 12px
    }

        .faq-a-inner p:last-child {
            margin-bottom: 0
        }

    .faq-a-inner strong {
        color: var(--ink);
        font-weight: 500
    }

/* AUTHOR */
.tx-author {
    margin-top: 64px;
    background: var(--bg-warm);
    border: 1px solid var(--rule);
    border-radius: 18px;
    padding: 40px;
    display: grid;
    grid-template-columns: 130px 1fr;
    gap: 32px;
    align-items: start;
    box-shadow: var(--shadow-card)
}

@media (max-width:640px) {
    .tx-author {
        grid-template-columns: 1fr;
        text-align: left
    }
}

.tx-author-avatar {
    width: 130px;
    height: 130px;
    border-radius: 50%;
    background: linear-gradient(135deg,var(--teal-pale) 0%,var(--bg-warm) 100%);
    border: 2px solid var(--white);
    box-shadow: var(--shadow-card);
    display: flex;
    align-items: center;
    justify-content: center;
    font-family: 'Cormorant Garamond',serif;
    font-style: italic;
    font-size: 46px;
    color: var(--teal);
    position: relative
}

.tx-author-avatar-note {
    position: absolute;
    bottom: -22px;
    left: 50%;
    transform: translateX(-50%);
    font-size: 9px;
    color: var(--ink-mute);
    font-style: italic;
    font-family: 'Cormorant Garamond',serif;
    white-space: nowrap;
    letter-spacing: .04em
}

.tx-author-meta-top {
    font-size: 10px;
    font-weight: 600;
    letter-spacing: .2em;
    text-transform: uppercase;
    color: var(--amber);
    margin-bottom: 10px
}

.tx-author-name {
    font-family: 'Cormorant Garamond',serif;
    font-size: 34px;
    font-weight: 400;
    color: var(--ink);
    line-height: 1.1;
    margin-bottom: 8px
}

    .tx-author-name em {
        font-style: italic;
        color: var(--teal)
    }

.tx-author-cred {
    font-size: 13.5px;
    color: var(--ink-soft);
    line-height: 1.6;
    margin-bottom: 16px;
    letter-spacing: .02em
}

.tx-author-bio {
    font-size: 15px;
    font-weight: 300;
    color: var(--ink-mid);
    line-height: 1.75;
    margin-bottom: 20px;
    max-width: 620px
}

.tx-author-credentials {
    display: flex;
    gap: 24px;
    padding-top: 18px;
    border-top: 1px solid var(--rule);
    flex-wrap: wrap
}

.tx-author-cred-item {
    font-size: 11px;
    letter-spacing: .04em;
    color: var(--ink-soft)
}

    .tx-author-cred-item strong {
        color: var(--ink);
        font-weight: 500;
        display: block;
        margin-bottom: 2px
    }

.tx-author-link {
    display: inline-flex;
    align-items: center;
    gap: 10px;
    margin-top: 16px;
    font-size: 11px;
    font-weight: 600;
    letter-spacing: .14em;
    text-transform: uppercase;
    color: var(--ink);
    border-bottom: 1px solid var(--rule);
    padding-bottom: 4px;
    transition: all .25s
}

    .tx-author-link:hover {
        color: var(--teal);
        border-color: var(--teal)
    }

/* CITATIONS */
.tx-citations {
    margin-top: 48px;
    padding: 32px 36px;
    background: var(--white);
    border: 1px solid var(--rule);
    border-radius: 14px;
    box-shadow: var(--shadow-card)
}

    .tx-citations h3 {
        font-family: 'Cormorant Garamond',serif;
        font-size: 22px;
        font-weight: 500;
        color: var(--ink);
        margin-bottom: 20px
    }

        .tx-citations h3 em {
            font-style: italic;
            color: var(--amber);
            font-weight: 400
        }

.tx-cite {
    font-size: 13px;
    font-weight: 300;
    color: var(--ink-mid);
    line-height: 1.65;
    padding: 14px 0 14px 32px;
    border-bottom: 1px solid var(--rule-soft);
    position: relative;
    counter-increment: cite
}

.tx-citations-list {
    counter-reset: cite
}

.tx-cite:last-child {
    border-bottom: none
}

.tx-cite::before {
    content: counter(cite);
    position: absolute;
    left: 0;
    top: 14px;
    font-family: 'Cormorant Garamond',serif;
    font-style: italic;
    font-size: 14px;
    color: var(--amber);
    font-weight: 600;
    width: 24px;
    text-align: right
}

.tx-cite strong {
    color: var(--ink);
    font-weight: 500
}

.tx-cite a {
    color: var(--teal);
    border-bottom: 1px solid var(--rule);
    transition: border-color .25s
}

    .tx-cite a:hover {
        border-bottom-color: var(--teal)
    }

/* RELATED THERAPIES */
.tx-related-ther {
    padding: 90px 0;
    background: var(--bg-warm);
    border-top: 1px solid var(--rule)
}

.tx-related-head {
    max-width: 720px;
    margin-bottom: 48px
}

    .tx-related-head .eyebrow {
        margin-bottom: 18px
    }

    .tx-related-head h2 {
        font-family: 'Cormorant Garamond',serif;
        font-size: clamp(32px,4vw,48px);
        font-weight: 300;
        color: var(--ink);
        line-height: 1.05;
        letter-spacing: -.008em
    }

        .tx-related-head h2 em {
            font-style: italic;
            color: var(--teal)
        }

.rt-list {
    display: grid;
    grid-template-columns: repeat(3,1fr);
    gap: 14px;
    margin-top: 32px
}

@media (max-width:760px) {
    .rt-list {
        grid-template-columns: 1fr
    }
}

.rt-card {
    padding: 26px 28px;
    background: var(--white);
    border: 1px solid var(--rule);
    border-radius: 12px;
    transition: all .3s var(--ease-spring);
    box-shadow: var(--shadow-card)
}

    .rt-card:hover {
        border-color: var(--amber);
        transform: translateY(-3px);
        box-shadow: var(--shadow-soft)
    }

.rt-iso {
    font-family: 'Cormorant Garamond',serif;
    font-style: italic;
    font-size: 12.5px;
    color: var(--teal);
    margin-bottom: 8px;
    font-weight: 400
}

.rt-name {
    font-family: 'Cormorant Garamond',serif;
    font-size: 24px;
    font-weight: 500;
    color: var(--ink);
    line-height: 1.2;
    margin-bottom: 10px
}

    .rt-name em {
        font-style: italic;
        color: var(--teal);
        font-weight: 400
    }

.rt-for {
    font-size: 13px;
    color: var(--ink-soft);
    line-height: 1.6
}
 

@media (prefers-reduced-motion:reduce) {
    *, *::before, *::after {
        animation-duration: .01ms !important;
        transition-duration: .01ms !important
    }
}